Anti-MDM2 Monoclonal Antibody(Clone: MDM2/2414)
Product Sizes
20 µg
£397.00
36-2761-20UG
100 µg
£716.00
36-2761-100UG
About this Product
- SKU:
- 36-2761
- Additional Names:
- ACTFS; Double minute 2 protein; E3 ubiquitin-protein ligase; Hdm2; HDMX; MDM2; MDM2 oncogene E3 ubiquitin protein ligase; MDM2BP; Mouse Double Minute 2; MTBP; Murine Double Minute Chromosome 2; p53 Binding Protein Mdm2; p53-binding protein Mdm2
- translate.label.attr.clone:
- MDM2/2414
- Clonality:
- Monoclonal
- Extra Details:
- MDM2 is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53. It can promote tumor formation by targeting tumor suppressor proteins; such as p53; for proteasomal degradation. Overexpression of MDM2 can result in excessive inactivation of tumor protein p53; diminishing its tumor suppressor function. This protein also affects the cell cycle; apoptosis; and tumorigenesis throµgh interactions with other proteins; including retinoblastoma 1 and ribosomal protein L5. Overexpression of MDM2 protein is detected in a variety of cancers.
- Host:
- Mouse
- Immunogen:
- Recombinant human MDM2 protein fragment (around aa 126-254) (exact sequence is proprietary)
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
