Anti-DNA Ligase 1 Monoclonal Antibody(Clone: 1A9)
Product Sizes
20 µg
£397.00
36-2705-20UG
100 µg
£716.00
36-2705-100UG
About this Product
- SKU:
- 36-2705
- Additional Names:
- DNA ligase 1; DNA ligase I; DNLI1_HUMAN; LIG 1; lig1; Ligase I DNA ATP dependent; MGC117397; MGC130025; Polydeoxyribonucleotide synthase [ATP] 1
- Application:
- ELISA
- translate.label.attr.clone:
- 1A9
- Clonality:
- Monoclonal
- Extra Details:
- DNA Ligase I maintains the major DNA Ligase activity in proliferating cells by joining Okazaki fragments during lagging strand DNA replication. Human DNA Ligase I also has an essential role in DNA repair pathways; where it catalyzes the formation of phosphodiester bonds between adjacent 5' phosphoryl and 3' hydroxy termini at single breaks in duplex DNA molecules. In addition; DNA Ligase I plays a role in sealing nicks during excision repair. Similar to other DNA ligases; DNA Ligase I is built around a common catalytic core. Increased levels of DNA Ligase I are found in human tumors; as compared to benign tissues; as well as in peripheral blood lymphocytes. Furthermore; DNA Ligase I antisense ODNs syndrome (BS). Individuals with BS either have decreased levels of abnormally thermolabile DNA Ligase I or possess a dimeric form of this enzyme.
- Host:
- Mouse
- Immunogen:
- Full-length native cow LIG1 protein
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
