Anti-Lymphocyte Activation Gene 3 (LAG-3) (Negative Checkpoint Regulator) Monoclonal Antibody(Clone: LAG3/3261)
Product Sizes
20 µg
£397.00
36-2698-20UG
100 µg
£716.00
36-2698-100UG
About this Product
- SKU:
- 36-2698
- Additional Names:
- CD223; FDC protein; LAG-3
- translate.label.attr.clone:
- LAG3/3261
- Clonality:
- Monoclonal
- Extra Details:
- LAG-3 (also called CD223) is a high affinity MHC class II ligand present on the surface of CD4+CD8+ T cells and NK cell; with shared homology in structure to CD4 molecules. It has a glutamic acid-proline (EP) repetitive sequence found in other functionally distinct mammalian; parasitic; and bacterial proteins that may influence a conserved biological function. LAG-3+CD4+CD8+ T cells can associate with the T cell receptor (TCR) and downregulate TCR signaling in vitro. LAG-3 inhibits CD4-dependent T cell function via its cytoplasmic domain. LAG-3 Lys-468 within a conserved 'KIEELE' motif is essential for interaction with downstream signaling molecules. Furthermore; as a checkpoint inhibitor target; it may be superior to CTLA-4 and PD-1 since both antibodies only activate effector T-cells; whereas an antagonist LAG-3 antibody can both activate T effector cells (by downregulating the LAG-3 inhibiting signal into pre-activated LAG-3+ cells) and inhibit induced (i.e. antigen-specific) Treg suppressive activity.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human LAG3 protein
- Isotype:
- Mouse IgG2a; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
