Anti-HSP60 (Heat Shock Protein 60) (Mitochondrial Marker) Monoclonal Antibody(Clone: CPTC-HSPD1-1)
Product Sizes
20 µg
£397.00
36-2509-20UG
100 µg
£716.00
36-2509-100UG
About this Product
- SKU:
- 36-2509
- Additional Names:
- 60kDa chaperonin; 60kDa heat shock protein mitochondrial; Chaperonin; 60-KD (CPN60); GROEL; HLD4; HSP65; HSPD1; HuCHA60; Mitochondrial matrix protein P1; P60 lymphocyte protein; Short heat shock protein 60 Hsp60s1; Spastic paraplegia 13 (SPG13)
- translate.label.attr.clone:
- CPTC-HSPD1-1
- Clonality:
- Monoclonal
- Extra Details:
- The heat shock proteins (HSPs) comprise a group of highly conserved; abundantly expressed proteins with diverse functions; including the assembly and sequestering of multiprotein complexes; transportation of nascent polypeptide chains across cellular membranes; and the regulation of protein folding. The mitochondrial and cytosolic localization of HSP60; combined with its binding and catalysis of folding of newly synthesized proteins destined for the mitochondrial matrix; classify this protein as a molecular chaperone. An additional role of HSP 60 is to act as a cell surface marker for T cell recognition; as well as being involved in a danger signal cascade immune response. HSP60 has been shown to influence apoptosis in tumor cells; and changes in its expression level may serve as a biomarker; as down-regulated HSP60 expression indicates a poor prognosis as well as a risk of tumor infiltration development; especially with regard to urothelial carcinomas. In ovarian cancer; decreased expression of HSP60 correlates with aggressive tumor types; while overexpression is correlated with a better patient prognosis.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human HSPD1 protein
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
