Anti-HIF1 alpha (Hypoxia-Inducible Factor 1-alpha) Monoclonal Antibody(Clone: ESEE122)
Product Sizes
20 µg
£397.00
36-2471-20UG
100 µg
£716.00
36-2471-100UG
About this Product
- SKU:
- 36-2471
- Additional Names:
- ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; Class E basic helix-loop-helix protein 78 (bHLHe78); Member of PAS superfamily 1 (MOP1); PAS domain-containing protein 8 (PASD8)
- translate.label.attr.clone:
- ESEE122
- Clonality:
- Monoclonal
- Extra Details:
- HIF1 (hypoxia-inducible factor 1); a heterodimeric transcription factor complex central to cellular response to hypoxia; consists of two subunits (HIF-1 alpha and HIF-1 beta) which are basic helix-loop-helix proteins of the PAS (Per; ARNT; Sim) family. Expression of HIF-1 alpha protein is regulated by cellular oxygen level alterations as well as in oxygen-independent manner via different cytokines (throµgh the PI3K-AKT-mTOR pathway); growth factors; oncogenic activation; or loss of tumor suppressor function etc. In normoxic cells; HIF-1 alpha is proline hydroxylated leading to a conformational change that promotes its binding to the VLH (von Hippel Lindau) protein E3 ligase complex; ubiquitination and followed by rapid proteasomal degradation. Hypoxia as well as chemical hydroxylase inhibitors (desferrioxamine; cobalt etc.) inhibit HIF-1 alpha degradation and lead to its accumulation in the cells; whereas; contrastingly; HIF-1 beta/ARNT (AhR nuclear translocator) remains stable under both conditions. Besides their critical role in hypoxic response; HIF1s regulates the transcription of genes responsible for angiogenesis; erythropoiesis/iron-metabolism; glucose metabolism; cell proliferation/survival; adipogenesis; carotid body formation; B lymphocyte development and immune reactions.
- Host:
- Mouse
- Immunogen:
- GST-human HIF-1A amino acids 329-530 fusion protein
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
