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Antibodies

Anti-MSH6 (DNA Mismatch Repair Protein) Monoclonal Antibody(Clone: MSH6/2927)

Product Sizes
20 µg
£397.00
36-2439-20UG
100 µg
£716.00
36-2439-100UG
About this Product
SKU:
36-2439
Additional Names:
DNA mismatch repair protein Msh6; G/T mismatch-binding protein; GTBP; GTMBP; hMSH6; HNPCC5; HSAP; MSH6; mutS (E. coli) homolog 6; MutS alpha 160kDa subunit; MutS-alpha 160kDa subunit; p160; Sperm associated protein
translate.label.attr.clone:
MSH6/2927
Clonality:
Monoclonal
Extra Details:
The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially; inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes mutS and mutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. A member of the mismatch repair family; GTBP (also designated MSH6); is an MSH2-related protein that binds to DNA containing G/T mismatches. Findings sµggest that the mismatch-binding factor in human cells is composed of a heterodimer of GTBP and MSH2.
Host:
Mouse
Immunogen:
Recombinant fragment of human MSH6 protein (around aa 374-540) (exact sequence is proprietary)
Isotype:
Mouse IgG2b; kappa
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
  • Manufacturer's Data Sheet:1.jpg
Fig. 2: Formalin-fixed; paraffin-embedded human Lymph Node stained with MSH6 Mouse Monoclonal Antibody (MSH6/2927).
Fig. 3: SDS-PAGE Analysis Purified MSH6 Mouse Monoclonal Antibody (MSH6/2927). Confirmation of Purity and Integrity of Antibody.
Fig. 4: Analysis of Protein Array containing >19;000 full-length human proteins using MSH6 Mouse Monoclonal Antibody (MSH6/2927) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targe
Fig. 4: Analysis of Protein Array containing >19;000 full-length human proteins using MSH6 Mouse Monoclonal Antibody (MSH6/2927) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targe