Anti-Gelsolin / Actin-depolymerizing Factor Monoclonal Antibody(Clone: CPTC-Gelsolin-1)
Product Sizes
20 µg
£397.00
36-2433-20UG
100 µg
£716.00
36-2433-100UG
About this Product
- SKU:
- 36-2433
- Additional Names:
- Actin depolymerizing factor; ADF; AGEL; Brevin; Gsn
- translate.label.attr.clone:
- CPTC-Gelsolin-1
- Clonality:
- Monoclonal
- Extra Details:
- Gelsolin (also known as brevin; Actin-depolymerizing factor or ADF); a proteinof leukocytes; platelets and other cells; severs Actin filaments in thepresence of submicromolar calcium; thereby isolating cytoplasmic Actin gels. It is a calcium-regulated; actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments; preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. Defects in GSN are the cause of amyloidosis type 5 (AMYL5); also known as familial amyloidosis Finnish type; typically characterized by cranial neuropathy and lattice corneal dystrophy. Severe systemic disease can develop in some individuals causing peripheral polyneuropathy; amyloid cardiomyopathy; and nephrotic syndrome leading to renal failure.
- Host:
- Mouse
- Immunogen:
- Recombinant human full-length protein
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
