Anti-CD32 (Fc Gamma RIIa) Monoclonal Antibody(Clone: 7.3)
Product Sizes
20 µg
£397.00
36-2281-20UG
100 µg
£716.00
36-2281-100UG
About this Product
- SKU:
- 36-2281
- Additional Names:
- CD32A; Fc fragment of IgG low affinity IIa receptor; Fc gamma RIIa; Fc-gamma RII-a; Fc-gamma-RIIa; FCGR2A; FcgRII; Fcr-2; FcRII-a; IGFR2; IgG Fc receptor II-a; Low affinity immunoglobulin gamma Fc region receptor II-a; Ly-17; Ly-m20; LyM-1; Lymphocyte antigen 17
- Clonality:
- Monoclonal
- Extra Details:
- This MAb reacts with a CD32 (FcgRII) epitope (cluster-4). It displays a stronger reaction with Daudi than with U937 cells. The epitope is located in domain 2 of FcgRIIa. Its Fab'2 fragments block immune complex binding. CD32 (FcRII) is a type 1 transmembrane glycoprotein that mediates several functions including phagocytosis; cytotoxicity; and immunomodulation as well as platelet aggregation. Three genes (A; B; and C) encode CD32 and at least 6 isoforms are generated via alternative mRNA splicing; i.e.; IIa1; IIa2; IIb1; IIb2; IIb3 and IIc. Monocytes/macrophages; placental trophoblasts and endothelial cells express all isoforms. In addition; the IIb isoform is expressed by B cells; and the IIa isoform by platelets; granulocytes and; weakly; by B cells. NK cells and neutrophils express Isoform IIc. CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes.
- Host:
- Mouse
- Immunogen:
- K562 and FcgRII+L cells
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
