Anti-TIGIT / VSTM3 / VSIG9 (Immune Checkpoint for Cancer) Monoclonal Antibody(Clone: TIGIT/3017)
Product Sizes
20 µg
£397.00
36-2212-20UG
100 µg
£716.00
36-2212-100UG
About this Product
- SKU:
- 36-2212
- Additional Names:
- T-cell immunoreceptor with Ig and ITIM domains; V-set and immunoglobulin domain containing 9 (VSIG9); V-set and transmembrane domain containing 3 (VSTM3); Washington University cell adhesion molecule (WUCAM)
- translate.label.attr.clone:
- TIGIT/3017
- Clonality:
- Monoclonal
- Extra Details:
- TIGIT is a checkpoint inhibitor which binds with high affinity to the poliovirus receptor (PVR); causing increased IL10 secretion; decreased IL12B secretion. TIGIT binding to PVR also causes the suppression of T cell activation by promoting the generation of mature immuno-regulatory dendritic cells. It is expressed at low levels on natural killer (NK) cells; as well as peripheral memory and regulatory CD4+ T cells. At the protein level; it is upregulated following the activation of these cells. Functionally; TIGIT is similar to CTLA4. The ligands for TIGIT include CD155 (signal abrogation) and CD226 (signal stimulation). It has been demonstrated to be upregulated on T cells in many cancers and is an immuno-oncology target for therapy.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa 22-141) of human TIGIT protein (exact sequence is proprietary)
- Isotype:
- Mouse IgG2c; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
