Anti-Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) Monoclonal Antibody(Clone: SPM322)
Product Sizes
20 µg
£397.00
36-2190-20UG
100 µg
£716.00
36-2190-100UG
About this Product
- SKU:
- 36-2190
- Additional Names:
- ECGF; ECGF1; Gliostatin; hPD-ECGF; MEDPS1; MNGIE; MTDPS1; PD-ECGF; PDECGF; Platelet-derived endothelial cell growth factor; TdRPase; Thymidine phosphorylase; TP; Tymp
- translate.label.attr.clone:
- SPM322
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a protein (amino acid 482) of 55kDa (in vivo 110kDa homodimer); identified as platelet-derived endothelial growth factor (PD-ECGF); same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate; it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines; cytotoxic agents used in the treatment of a variety of malignancies; into active cytotoxic metabolites (e.g. 5'-deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human Thymidine Phosphorylase (TP / PD-ECGF) protein
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
