Anti-Desmoglein-3 (Squamous Cell Marker) Monoclonal Antibody(Clone: DSG3/2839)
Product Sizes
20 µg
£397.00
36-2188-20UG
100 µg
£716.00
36-2188-100UG
About this Product
- SKU:
- 36-2188
- Additional Names:
- 130kDa pemphigus vulgaris antigen (PVA); Balding (Bal); Cadherin family member 6 (CDHF6); Desmoglein-3 (DSG3)
- translate.label.attr.clone:
- DSG3/2839
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a protein of 130kDa; identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80%) and specificity (100%) in recognizing squamous cell carcinoma (SqCC). Therefore; DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover; studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa 379-491) human DSG3 protein (exact sequence is proprietary)
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
