Skip to content

Basket

You currently have no items in your basket.

Total (excl. vat) £0.00
View basket & checkout
Antibodies

Anti-Desmoglein-3 (Squamous Cell Marker) Monoclonal Antibody(Clone: DSG3/2840)

Product Sizes
20 µg
£397.00
36-2181-20UG
100 µg
£716.00
36-2181-100UG
About this Product
SKU:
36-2181
Additional Names:
130kDa pemphigus vulgaris antigen (PVA); Balding (Bal); Cadherin family member 6 (CDHF6); Desmoglein-3 (DSG3)
translate.label.attr.clone:
DSG3/2840
Clonality:
Monoclonal
Extra Details:
Recognizes a protein of 130kDa; identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80%) and specificity (100%) in recognizing squamous cell carcinoma (SqCC). Therefore; DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover; studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis.
Host:
Mouse
Immunogen:
Recombinant fragment (around aa 379-491) human DSG3 protein (exact sequence is proprietary)
Isotype:
Mouse IgG1; kappa
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
  • Manufacturer's Data Sheet:1.jpg
Fig. 2: Formalin-fixed; paraffin-embedded human Esophageal Carcinoma stained with Desmoglein-3 Mouse Monoclonal Antibody (DSG3/2840).
Fig. 3: SDS-PAGE Analysis of Purified Desmoglein-3 Mouse Monoclonal Antibody (DSG3/2840). Confirmation of Purity and Integrity of Antibody
Fig. 4: Analysis of Protein Array containing more than 19;000 full-length human proteins using Desmoglein-3 Mouse Monoclonal Antibody (DSG3/2840) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on tha
Fig. 4: Analysis of Protein Array containing more than 19;000 full-length human proteins using Desmoglein-3 Mouse Monoclonal Antibody (DSG3/2840) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on tha