Anti-DMC1 Monoclonal Antibody (Clone: 2H12/4)
Product Sizes
20 µg
£397.00
36-2082-20UG
100 µg
£716.00
36-2082-100UG
About this Product
- SKU:
- 36-2082
- Additional Names:
- Disrupted meiotic cDNA 1 homolog; dJ199H16.1; DMC1 dosage suppressor of mck1 homolog; DMC1H; DNA meiotic recombinase 1; HsLim15; LIM15; Meiotic recombination protein DMC1/LIM15 homolog; MGC150472; MGC150473
- translate.label.attr.clone:
- 2H12/4
- Clonality:
- Monoclonal
- Extra Details:
- DNA repair proteins are necessary for the maintenance of chromosome integrity and are involved in the elimination of premutagenic lesions from DNA. The DNA repair proteins Rad51 and Rad52 are key components of the doublestrand-break repair (DSBR) pathway. Rad51 is essential for mitotic and meiotic recombination; and its mutation in yeast and mammalian cells results in chromosome loss. Overexpression of Rad52 confers resistance to ionizing radiation and induces homologous intrachromosomal recombination. Rad52 is thought to be involved in an early stage of Rad51-mediated recombination. Additional proteins involved in the pathway include Nibrin and Dmc1. Nibrin; which complexes with Mre11 and Rad50; is absent in Nijemegen breakage syndrome (NBS) patients. Dmc1 is specifically involved in meiotic recombination. An alternative spliced form of Dmc1; designated Dmc1-D; is deleted for a region between the two motifs involved in nucleotide binding. The alternatively spliced Dmc1-D transcript is detected in both male and female germ cells; indicating that the encoded protein may have a role in mammalian genetic recombination in meiosis.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human DMC1 protein.
- Isotype:
- Mouse IgG2a; kappa
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
