Anti-p27Kip1 (Mitotic Inhibitor/Suppressor Protein) Monoclonal Antibody (Clone: SX53G8)-CF488
Product Sizes
0.5 at 100 ml at µg/ml
£716.00
36-2026-0.5AT100MLATUG
About this Product
- SKU:
- 36-2026
- Additional Names:
- CDKN1B; CDKN4; Cyclin Dependent Kinase Inhibitor 1B; Cyclin-dependent kinase inhibitor p27 Kip1; KIP1; MEN1B; MEN4
- translate.label.attr.clone:
- SX53G8
- Clonality:
- Monoclonal
- Conjugate:
- CF488
- Extra Details:
- This MAb recognizes a 27kDa protein; identified as the p27Kip1; a cell cycle regulatory mitotic inhibitor. It is highly specific and shows no cross-reaction with other related mitotic inhibitors. In Western blotting of cell lysates from 7 human breast cancer cell lines (ZR75-1; ZR75-30; MCF-7; MDAMB453; T47D; CAL51; 734B); the antibody labels a single band corresponding to p27Kip1. It functions as a negative regulator of G1 progression and has been proposed to function as a possible mediator of TGF-alpha induced G1 arrest. p27Kip1 is a candidate tumor suppressor gene. Reportedly; low p27 expression has been associated with unfavorable prognosis in renal cell carcinoma; colon carcinoma; breast carcinomas; non-small-cell lung carcinoma; hepatocellular carcinoma; multiple myeloma; and lymph node metastases in papillary carcinoma of the thyroid; as well as a more aggressive phenotype in carcinoma of the cervix.
- Host:
- Mouse
- Immunogen:
- Purified GST-p27 fusion protein of human origin
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
