Anti-Occludin (Marker of Early Blood Brain Barrier Damage) Monoclonal Antibody (Clone: OCLN/2181)
Product Sizes
20 µg
£397.00
36-2007-20UG
100 µg
£716.00
36-2007-100UG
About this Product
- SKU:
- 36-2007
- Additional Names:
- BLCPMG; Occludin; OCLN; Phosphatase 1 regulatory subunit 115; PTORCH1; Tight junction protein occludin
- translate.label.attr.clone:
- OCLN/2181
- Clonality:
- Monoclonal
- Extra Details:
- Occludin is a tetraspan integral membrane protein in epithelial and endothelial tight junction (TJ) structures that can contain two extracellular loops. The protein exists in a variety of phosphorylated forms. Phosphorylation is involved in regulating both the localization and the function of Occludin. Expression of Occludin is upregulated by polyunsaturated fatty acids; increasing trans-endothelial cell resistance and reducing cellular permeability to large molecules. The level of Occludin varies greatly depending on tissue; in brain tissue; Occludin is highly expressed at cell-cell contact sites. Non-neural tissues show lower expression and discontinuous distribution. Occludin is a tight junction protein that is a key structural component of the blood-brain barrier (BBB). Degradation of Occludin is frequently seen in ischemic stroke and contributes to BBB disruption.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment of human Occludin protein (around aa 282-415) (exact sequence is proprietary)
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
