Anti-N-Cadherin / Cadherin-2 / CD325 (NCAD) Monoclonal Antibody (Clone: 8C11)
Product Sizes
20 µg
£397.00
36-2004-20UG
100 µg
£716.00
36-2004-100UG
About this Product
- SKU:
- 36-2004
- Additional Names:
- Cadherin-2 N cadherin neuronal; Cadherin-2 type 1; Cadherin-2; Calcium dependent adhesion protein neuronal; CD325; CDH2; CDHN; CDw325; N-Cadherin; NCAD
- translate.label.attr.clone:
- 8C11
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a protein of ~140kDa; identified as N-Cadherin (NCAD); also known as CD325. NCAD is a member of the Cadherin superfamily; and consists of five extracellular repeats; a transmembrane domain and a cytoplasmic domain. CD325 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this; CD325 has been implicated in several aspects of cardiac development including the precardiac mesoderm; establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore; CD325 is normally involved in inducing cell cycle arrest and its expression is frequently deregulated in cancer cells.Studies have linked N-cadherin to cancer metastasis by showing the aggressive tumor cells had preferentially turned on N-cadherin as opposed to E- or P-cadherin.
- Host:
- Mouse
- Immunogen:
- Recombinant human N-cadherin extracellular domain
- Isotype:
- Mouse IgG1; kappa
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
