Monoclonal Antibody to CD269 / TNFRSF17 / BCMA (B-Cell Maturation Protein) (MHC II)(Clone : BCMA/2366)
Product Sizes
20 µg
£397.00
36-2003-20UG
100 µg
£716.00
36-2003-100UG
About this Product
- SKU:
- 36-2003
- Additional Names:
- B-cell maturation protein; BCMA; CD269; TNR17; Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)
- translate.label.attr.clone:
- BCMA/2366
- Clonality:
- Monoclonal
- Extra Details:
- The B cell maturation protein (BCMA) is a type I integral membrane protein that belongs to the tumor necrosis factor receptor (TNF-alpha) superfamily. It is expressed as a 184 amino acid peptide that is expressed only in mature B-lymphocytes and is located on the cis part of the Golgi apparatus. BCMA shares significant homology with TACI (transmembrane activator) within the cysteine-rich domain. TACI has been shown to bind CAML; which induces activation of NFAT (nuclear factor of activated T cells). Both BCMA and TACI have been shown to bind APRIL and TALL-1; which stimulate B cell proliferation in conjunction with other B-cell activators. When overexpressed; TALL-1 stimulates the development of systemic lupus erythaematosus (SLE).
- Host:
- Mouse
- Immunogen:
- Recombinant human CD269 protein fragment (around aa 78-184) (exact sequence is proprietary)
- Isotype:
- Mouse / IgG2c; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
