Mouse Monoclonal Antibody To N-Cadherin (Clone: 13A9)
Product Sizes
100 µg
£716.00
36-2000-100UG
About this Product
- SKU:
- 36-2000
- translate.label.attr.clone:
- 13A9
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a protein of ~140kDa; identified as N-Cadherin (NCAD); also known as CD325. NCAD is a member of the Cadherin superfamily; and consists of five extracellular repeats; a transmembrane domain and a cytoplasmic domain. CD325 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this; CD325 has been implicated in several aspects of cardiac development including the precardiac mesoderm; establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore; CD325 is normally involved in inducing cell cycle arrest and its expression is frequently deregulated in cancer cells. Studies have linked N-cadherin to cancer metastasis by showing the aggressive tumor cells had preferentially turned on N-cadherin as opposed to E- or P-cadherin.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Recombinant human N-cadherin cytoplasmic domain (exact sequence is proprietary)
- Isotype:
- Mouse IgG1; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
