Monoclonal Antibody to Major Vault Protein (MVP)(Clone : 1032)
Product Sizes
100 µg
£716.00
36-1990-100UG
About this Product
- SKU:
- 36-1990
- Additional Names:
- MVP||LRP
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a protein of 104kDa-110kDa; characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology; including several small molecules of RNA; but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen; progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Proteins precipitated from human breast cancer MCF-7 cells
- Isotype:
- Mouse IgG1; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
