Monoclonal Antibody to CD74 (B-Cell Marker)(Clone : CLIP/1133)
Product Sizes
100 µg
£716.00
36-1976-100UG
About this Product
- SKU:
- 36-1976
- translate.label.attr.clone:
- CLIP/1133
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes proteins of 33; 35 and 41kDa; which are identified as various isoforms of CD74. Its epitope is localized in the extracellular domain of CD74. CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. The CD74 molecule plays a critical role in the presentation of peptides; by the MHC class II antigens; to CD4 positive lymphocytes. CD74 is expressed on MHC class II positive cells including B cells; a subset of activated T cells; monocytes; and dendritic cells and by various types of carcinomas. CD74 is expressed primarily by antigen presenting cells; such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage); macrophages; and monocytes; and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas; but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human CD74 protein
- Isotype:
- Mouse IgG1; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
