Monoclonal Antibody to CD59 / Complement Regulatory Protein / Protectin(Clone : MACIF/1193)
Product Sizes
100 µg
£716.00
36-1955-100UG
About this Product
- SKU:
- 36-1955
- Additional Names:
- CD59||MIC11||MIN1||MIN2||MIN3||MSK21
- translate.label.attr.clone:
- MACIF/1193
- Clonality:
- Monoclonal
- Extra Details:
- Reacts with human CD59; a 20kDa glycosyl phosphatidyl-inositol (GPI)-anchored cell surface protein. CD59 regulates complement-mediated cell lysis; and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex; whereby it binds complement C8 and/or C9 during the assembly of this complex; thereby inhibiting the incorporation of multiple copies of C9 into the complex; which is necessary for osmolytic pore formation. CD59 is widely distributed on cells in all tissues. It inhibits formation of MAC; thus protecting cells from complement-mediated lysis. The expression of CD59 on erythrocytes is important for their survival. Genetic defects in GPI-anchor attachment; that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH). It is useful for study on GPI-anchored proteins; PNH and CD59 functions.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human CD59 protein
- Isotype:
- Mouse IgM; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
