Monoclonal Antibody to CD53 (TSPAN25)(Clone : 161-2)
Product Sizes
100 µg
£716.00
36-1950-100UG
About this Product
- SKU:
- 36-1950
- Additional Names:
- CD53||MOX44||TSPAN25
- translate.label.attr.clone:
- 161-2
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a protein of 33-55kDa; identified as CD53 (Workshop VI; Code N-L033). It is expressed on monocytes and macrophages; dendritic cells; osteoblasts and osteoclasts; and on T and B cells from every stage of differentiation but is absent from platelets; red blood cells. CD53 appears to be the marker with widest reactivity as well as the marker with the strictest specificity to hematopoietic cells. CD53 is a type III membrane with both termini in the cytoplasm and two loops in the extracellular environment. This molecule; in common with other members of tetraspan family; is involved in cellular activation as part of a signal transduction complex involving other membrane glycoproteins. CD53 crosslinking induces calcium flux on human monocyte and B cells. Cross-linking of CD53 promotes activation of resting human B-lymphocytes. This MAb recognizes CD53 transfected cells and partially inhibits T-cell proliferation induced by CD3 antibody (clone: UCHT1).
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Stimulated human leukocytes
- Isotype:
- Mouse IgG2a; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
