Monoclonal Antibody to CD53 (TSPAN25)(Clone : 63-5A3)
Product Sizes
100 µg
£716.00
36-1949-100UG
About this Product
- SKU:
- 36-1949
- Additional Names:
- CD53||MOX44||TSPAN25
- translate.label.attr.clone:
- 63-5A3
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a protein of 33-55kDa; identified as CD53 (Workshop V; Code CD53.1). CD53 is expressed on monocytes; and macrophages; granulocytes; dendritic cells; osteoblasts and osteoclasts; NK cells; and on T- and B-cells from every stage of differentiation but is absent from platelets; erythrocytes; and non-haemopoietic cells. CD53 is a member of a family of tetraspan transmembrane proteins; including CD9; CD37; CD63; CD81; and CD82. It associates with integrins; MHC class II molecules; and a tyrosine phosphatase and plays a role in cellular activation as part of a signal transduction complex involving other membrane glycoproteins. Defects of CD53 expression on neutrophils appear to be related with recurrent infectious diseases. Cross-linking CD53 using CD53 antibodies led to cytoplasmic calcium fluxes in B cells; monocytes; and granulocytes and activation of the monocyte oxidative burst.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Human Sezary cells
- Isotype:
- Mouse IgG2b; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
