Monoclonal Antibody to Cyclin B1 (G2- & M-phase Cyclin)(Clone : CCNB1/1098)

Product Sizes

100 µg

£716.00

36-1834-100UG

About this Product

SKU:: 36-1834
Additional Names:: CCNB1||CCNB
translate.label.attr.clone:: CCNB1/1098
Clonality:: Monoclonal
Extra Details:: It recognizes a protein of 55-62kDa; identified as cyclin B1. In mammals; cyclin B associates with inactive p34cdc2; which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis; when Cdc25; a specific protein phosphatase; dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So; cyclin B-p34cdc2 plays a critical role in G2 to M transition.
Format:: Purified
Host:: Mouse
Immunogen:: Recombinant human full-length CCNB1 protein
Isotype:: Mouse IgG1; kappa
Purification:: Affinity Chromatography
Reactivities:: Human, Mouse
Shipping Conditions:: Blue Ice
Storage Conditions:: Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
Supplier:: Abeomics
Type:: Antibodies:Monoclonal Antibody

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