Monoclonal Antibody to ZAP70 (Chronic Lymphocytic Leukemia Marker)(Clone : 2F3.2)
Product Sizes
100 µg
£716.00
36-1812-100UG
About this Product
- SKU:
- 36-1812
- Additional Names:
- ZAP70||SRK
- translate.label.attr.clone:
- 2F3.2
- Clonality:
- Monoclonal
- Extra Details:
- ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells. Control of this protein translation is via the IgVH gene. In Western blotting of whole cell lysates of normal peripheral blood mononuclear cells; the antibody labels a band corresponding to ZAP70. In Western blotting of whole cell lysates of CD19-positive purified leukemia cells from patients with Ig-unmutated and Ig-mutated CLL; the antibody labels a band corresponding to ZAP70 in the Ig-unmutated CLL samples; whereas no band is observed in the Ig-mutated CLL samples. In Western blotting of cell lysates of Jurkat cells (T-lymphoblastic cell line); the antibody labels a band of 70kDa protein. In Western blotting of cell lysates of A431 cells (carcinoma cell line); no band is observed. ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well. Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Recombinant ZAP-70 protein including residues 1-254 and encompassing SH2 domains of human ZAP70
- Isotype:
- Mouse IgG2a; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
