Monoclonal Antibody to Tyrosinase (Melanoma Marker)(Clone : T311)
Product Sizes
100 µg
£716.00
36-1776-100UG
About this Product
- SKU:
- 36-1776
- Additional Names:
- TYR
- translate.label.attr.clone:
- T311
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a cluster of proteins between 70-80kDa; identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1; TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3;4-dihydroxy-phenylalanine (dopa); and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Recombinant tyrosinase protein
- Isotype:
- Mouse IgG2a; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
