Monoclonal Antibody to Thymidylate Synthase (5-FU Resistance Marker)(Clone : SPM453)
Product Sizes
100 µg
£716.00
36-1773-100UG
About this Product
- SKU:
- 36-1773
- Additional Names:
- TYMS||TS||OK/SW-cl.29
- translate.label.attr.clone:
- SPM453
- Clonality:
- Monoclonal
- Extra Details:
- It recognizes a protein of 36kDa; identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP); which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines; an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5;10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal; gastric; head and neck; and breast carcinomas.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Recombinant human thymidylate synthase
- Isotype:
- Mouse IgG1; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
