Monoclonal Antibody to p53 Tumor Suppressor Protein(Clone : TRP/816)
Product Sizes
100 µg
£716.00
36-1762-100UG
About this Product
- SKU:
- 36-1762
- Additional Names:
- TP53||P53
- translate.label.attr.clone:
- TRP/816
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a 53kDa protein; which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth; replication; and apoptosis. It binds to MDM2; SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma; lung carcinoma; colorectal; and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors; including breast; ovarian; bladder; colon; lung; and melanoma.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Recombinant human TP53 protein
- Isotype:
- Mouse IgG2a; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
