Monoclonal Antibody to TNF-alphalpha (Tumor Necrosis Factor alpha)(Clone : TNF706)
Product Sizes
100 µg
£716.00
36-1751-100UG
About this Product
- SKU:
- 36-1751
- Additional Names:
- TNF||TNFA||TNFSF2
- translate.label.attr.clone:
- TNF706
- Clonality:
- Monoclonal
- Extra Details:
- Tumor Necrosis Factor Alpha (TNF alpha) is a protein secreted by lipopolysaccharide-stimulated macrophages; and causes tumor necrosis when injected into tumor bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two; three; or five non-covalently linked units; but shows a single 17kDa band following SDS PAGE under non-reducing conditions. TNF alpha is closely related to the 25kDa protein Tumor Necrosis Factor beta (lymphotoxin); sharing the same receptors and cellular actions. TNF alpha causes cytolysis of certain transformed cells; being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells; TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines; activating polymorphonuclear neutrophils and osteoclasts; and induction of interleukin 1; prostaglandin E2 and collagenase production.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Recombinant N-terminal fragment of human TNF-alpha
- Isotype:
- Mouse IgM; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
