Monoclonal Antibody to TNF-alphalpha (Tumor Necrosis Factor alpha)(Clone : TNFA/1172)
Product Sizes
100 µg
£716.00
36-1745-100UG
About this Product
- SKU:
- 36-1745
- Additional Names:
- TNF||TNFA||TNFSF2
- translate.label.attr.clone:
- TNFA/1172
- Clonality:
- Monoclonal
- Extra Details:
- This MAb recognizes human 17-26kDa protein; which is identified as cytokine TNF-alphalpha (Tumor Necrosis Factor-alpha). TNF-alphalpha can be expressed as a 17kDa free molecule; or as a 26kDa membrane protein. TNF-alphalpha is a protein secreted by lipopolysaccharide-stimulated macrophages; and causes tumor necrosis when injected into tumor bearing mice. TNF alpha causes cytolysis of certain transformed cells; being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells; TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines; activating polymorphonuclear neutrophils and osteoclasts; and induction of interleukin 1; prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human TNF-alphalpha protein
- Isotype:
- Mouse IgM; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
