Monoclonal Antibody to Transglutaminase II (TGM2)(Clone : TGM2/419)
Product Sizes
100 µg
£716.00
36-1734-100UG
About this Product
- SKU:
- 36-1734
- Additional Names:
- TGM2
- translate.label.attr.clone:
- TGM2/419
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a 77-85kDa protein; identified as cellular or tissue transglutaminase II (TGase II). Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved; they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer; is induced by retinoic acid; and appears to be involved in apoptosis. Finally; the encoded protein is the autoantigen implicated in celiac disease. The identification of transglutaminase as the main antigen of endomysium antibodies allows a new diagnostic approach to celiac disease (CD); a genetic; immunologically mediated small bowel enteropathy that causes malabsorption. TGase II is implicated in programmed cell death; signal transduction; drug-resistance; cell growth; endocytosis; insulin secretion; cell adhesion; cataract formation; and wound healing.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human TGM2 protein
- Isotype:
- Mouse IgG1; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
