Monoclonal Antibody to pS2 / pNR-2 / Trefoil Factor 1 (Estrogen-Regulated Protein)(Clone : GE2; same as R47/9
Product Sizes
100 µg
£716.00
36-1710-100UG
About this Product
- SKU:
- 36-1710
- Additional Names:
- TFF1||BCEI||PS2
- translate.label.attr.clone:
- GE2; same as R47/94
- Clonality:
- Monoclonal
- Extra Details:
- It recognizes a polypeptide of 6.5kDa; identified as pS2 estrogen-regulated protein. Its epitope is localized between aa57-84 of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds; forming the trefoil motif; or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic; often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa; gastric fluid; goblet cells in the colon and small intestine; and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Synthetic peptide of 28 amino acid residues corresponding to CFDDTVRGVPWCFYPNTIDVPPEEECEF (aa57-84) from the C-terminus of human pS2.
- Isotype:
- Mouse IgG1; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
