Monoclonal Antibody to SUMO-2/3(Clone : SM23/496)
Product Sizes
100 µg
£716.00
36-1686-100UG
About this Product
- SKU:
- 36-1686
- Additional Names:
- SUMO2||SMT3B||SMT3H2
- translate.label.attr.clone:
- SM23/496
- Clonality:
- Monoclonal
- Extra Details:
- This MAb reacts with both SUMO-2 and SUMO-3. The small ubiquitin-related modifier (SUMO) proteins; which include SUMO-1; 2 and 3; belong to the ubiquitin-like protein family. Like ubiquitin; the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also; both utilize the E1; E2 and E3 cascade enzymes for conjugation. However; SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation; whereas sumoylation targets proteins to a variety of cellular processing; including nuclear transport; transcriptional regulation; apoptosis and protein stability. The unconjugated SUMO-1; 2 and 3 proteins localize to the nuclear membrane; nuclear bodies and cytoplasm; respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins; which include MDM2; p53; PML and RanGap1. SUMO-2 and 3 contribute to a greater percentage of protein modification than does SUMO-1 and unlike SUMO-1; they can form polymeric chains. In addition; SUMO-3 regulates beta-Amyloid generation and may be critical in the onset or progression of Alzheimer's disease.
- Format:
- Purified
- Host:
- Mouse
- Isotype:
- Mouse IgG1; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
