Monoclonal Antibody to ACTH (Adrenocorticotrophic Hormone) (Pituitary Marker)(Clone : SPM333)
Product Sizes
100 µg
£716.00
36-1570-100UG
About this Product
- SKU:
- 36-1570
- Additional Names:
- POMC
- translate.label.attr.clone:
- SPM333
- Clonality:
- Monoclonal
- Extra Details:
- ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to Synacthen (aa1-24 of ACTH); does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive; tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP; ACTH; alpha-MSH (Melanocyte Stimulating Hormone); beta-MSH; gamma-MSH; CLIP (corticotropin-like intermediary peptide); Lipotropin-beta; Lipotropin-gamma; beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells; B-cells; and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Synthetic peptide corresponding to aa1-24 of human ACTH
- Isotype:
- Mouse IgG1; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
