Monoclonal Antibody to FOXP3 (Forkhead Box Protein P3) / Scurfin(Clone : SPM579)
Product Sizes
100 µg
£716.00
36-1535-100UG
About this Product
- SKU:
- 36-1535
- Additional Names:
- FOXP3||IPEX||JM2
- translate.label.attr.clone:
- SPM579
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a protein of 47-55kDa; which is identified as FOXP3. Its precise epitope is not known; but it has been mapped to the N-terminal portion of the protein. The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development; FOXP1 and FOXP2 are expressed abundantly in the lung; with lower levels of expression in neural; intestinal and cardiovascular tissues; where they act as transcription repressors. FOXP1 is widely expressed in adult tissues; while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX; a fatal; X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically; FOXP3 represses transcription through a DNA binding forkhead domain; thereby regulating T cell activation.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Full-length human FOXP3 protein
- Isotype:
- Mouse IgG1; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
