Monoclonal Antibody to Nuclear Mitotic Apparatus Protein (NuMA)(Clone : SPM300)
Product Sizes
100 µg
£716.00
36-1522-100UG
About this Product
- SKU:
- 36-1522
- Additional Names:
- NUMA1||NMP22||NUMA
- translate.label.attr.clone:
- SPM300
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a phosphorylated protein of 228kDa; identified as nuclear mitotic apparatus protein (NuMA). Its epitope is resistant to phosphatases. NuMA is intra-nuclear protein and present in nucleus during interphase. At the onset of mitosis; it redistributes from the nucleus to two centrosomal structures that later will become part of the mitotic spindle pole. After anaphase; the protein redistributes from the spindle polar region into reforming nucleus. NuMA is an essential protein during mitosis for the terminal phases of chromosome separation and/or nuclear reassembly. Recently a study shows that NuMA is cleaved to a 180 to 200kDa during apoptosis. Chromosomal translocation of this gene with the RARA (retinoic acid receptor; alpha) gene on chromosome 17 has been detected in patients with acute promyelocytic leukemia.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Colon carcinoma 174T cells
- Isotype:
- Mouse IgM; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
