Monoclonal Antibody to Microphthalmia Transcription Factor (MITF)(D5 + MITF/915)
Product Sizes
100 µg
£716.00
36-1436-100UG
About this Product
- SKU:
- 36-1436
- Additional Names:
- MITF||BHLHE32
- translate.label.attr.clone:
- D5 + MITF/915
- Clonality:
- Monoclonal
- Extra Details:
- MITF (microphthalmia transcription factor) is a basic helix-loop-helix-leucine-zipper (bHLH-Zip) transcription factor that regulates the development and survival of melanocytes and retinal pigment epithelium; and also is involved in transcription of pigmentation enzyme genes such as tyrosinase TRP1 and TRP2. MITF has been shown to be phosphorylated by MAP kinase in response to c-kit activation; resulting in upregulation of MITF transcriptional activity. Mutations of the MITF gene are associated with the autosomal dominant hereditary deafness and pigmentation condition; Waardenburg Syndrome type 2A. Multiple isoforms of MITF exist; including MITF-A; MITF-B; MITF-C; MITF-H; and MITF-M; which differ in the amino-terminal domain and in their expression patterns. The MITF-M isoform is restricted to the melanocyte cell lineage. Anti-MITF; D5; recognizes a nuclear protein; which is expressed in the majority of primary and metastatic epithelioid malignant melanomas as well as in normal melanocytes; benign nevi and dysplastic nevi.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- NH2 terminus fragment of human Mi protein (D5); Recombinant human MiTF protein (MITF/915)
- Isotype:
- Mouse IgG1; kappa + Mouse IgG1; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
