Monoclonal Antibody to CD46 (Membrane Cofactor Protein)(Clone : 122.2)
Product Sizes
100 µg
£716.00
36-1420-100UG
About this Product
- SKU:
- 36-1420
- Additional Names:
- CD46||MCP||MIC10
- Clonality:
- Monoclonal
- Extra Details:
- CD46 acts as a cofactor for complement factor I; a serine protease; which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells; which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10; and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Recombinant human CD46 protein
- Isotype:
- Mouse IgG1; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
