Monoclonal Antibody to Laminin; gamma 1 (LAMC1)(Clone : SPM193)
Product Sizes
100 µg
£716.00
36-1396-100UG
About this Product
- SKU:
- 36-1396
- Additional Names:
- LAMC1||LAMB2
- translate.label.attr.clone:
- SPM193
- Clonality:
- Monoclonal
- Extra Details:
- Laminins are large hetero-trimeric; non-collagenous glycoproteins composed of alpha ; beta ; and gamma chains. This MAb reacts with laminin B2/1 chain of ~210kDa and does not cross-react with other basement membrane components or fibronectin. Its specificity was established by immunoprecipitation and immunofluorescence of human skeletal muscle and kidney with laminin chain-specific MAbs. Epithelial sheets in vivo are separated from the mesenchymal elements of the stroma by a thin layer of a specialized type of extracellular matrix termed the basement membrane (BM). This structure consists of individual components; some of which are ubiquitous in BMs and some are not. The ubiquitous ones comprise laminin (LN); entactin/nidogen (EN); collagen type IV (CIV); and large heparan sulfate proteoglycan (HSPG); which interact specifically with each other to form a continuous and regular BM. Alterations of BM integrity; from local discontinuities up to complete loss; are described in many types of human and animal epithelial neoplasms. This MAb stains uniformly all human and murine basement membranes.
- Format:
- Purified
- Host:
- Rat
- Immunogen:
- Murine EHS laminin prepaRation
- Isotype:
- Rat IgG2a; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
