Monoclonal Antibody to Cytokeratin 6 (KRT6) (Hyperproliferation-Related Keratin)(Clone : SPM269)
Product Sizes
100 µg
£716.00
36-1343-100UG
About this Product
- SKU:
- 36-1343
- Additional Names:
- KRT6A||K6A||KRT6D
- translate.label.attr.clone:
- SPM269
- Clonality:
- Monoclonal
- Extra Details:
- This MAb recognizes a protein of 56kDa; identified as cytokeratin 6 (CK6). In humans; multiple isoforms of Cytokeratin 6 (6A-6F); encoded by several highly homologous genes; have distinct tissue expression patterns; and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13; and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes; which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Keratin 6 is found in hair follicles; suprabasal cells of a variety of internal stratified epithelia; in epidermis; in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes; which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- A synthetic peptide of 11 amino acids (GSSTIKYTTTS) from C-terminus of human keRatin 6
- Isotype:
- Mouse IgG2a; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
