Monoclonal Antibody to Involucrin (Squamous Cell Terminal Differentiation Marker)(Clone : SPM259)
Product Sizes
100 µg
£716.00
36-1331-100UG
About this Product
- SKU:
- 36-1331
- Additional Names:
- IVL
- translate.label.attr.clone:
- SPM259
- Clonality:
- Monoclonal
- Extra Details:
- It recognizes a protein of 66kDa-170kDa; identified as involucrin. In Western blotting of cultured human keratinocytes; this MAb reacts with a 120kDa protein. It stains the involucrin in a variety of sizes: 170kDa in MCF-7 cells; a doublet of ~115kDa and 150kDa in gorilla and owl monkey; 66kDa in dog; and a doublet of 105kDa in pig. Its epitope maps between codon 421-568 of human involucrin. Involucrin is expressed in a range of stratified squamous epithelia; including the cornea; which lacks a distinct cornified layer. In normal epidermis; it is first expressed in the upper spinous layers; and in keratinocyte cultures; all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias; involucrin expression begins closer to the basal layer than normal; expression is abnormal in squamous cell carcinomas and premalignant lesions; and is reduced in severe dysplasias of the larynx and cervix.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Purified involucrin from human keRatinocytes
- Isotype:
- Mouse IgG1; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
