Monoclonal Antibody to IDH1 (Isocitrate Dehydrogenase)(Clone : IDH1/1152)
Product Sizes
100 µg
£716.00
36-1257-100UG
About this Product
- SKU:
- 36-1257
- Additional Names:
- IDH1||PICD
- translate.label.attr.clone:
- IDH1/1152
- Clonality:
- Monoclonal
- Extra Details:
- It recognizes a 45kDa protein; which is identified as isocitrate dehydrogenase (IDH1). It belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 catalyzes the third step of the citric acid cycle; which involves the oxidative decarboxylation of isocitrate; forming alpha-ketoglutarate and CO2 in a two-step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate; while the second step involves the production of alpha-ketoglutarate. During this process; either NADH or NADPH is produced along with CO2. Recently; an inactivating mutation of IDH1 has been implicated in glioblastoma. IDH1 appears to function as a tumor suppressor that; when mutationally inactivated; contributes to tumorigenesis in part through induction of the HIF-1 pathway.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (119 Amino acid residues around aa 280-420) of human IDH1 protein
- Isotype:
- Mouse IgG1; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
