Monoclonal Antibody to Heparan Sulfate Proteoglycan (Large) / Perlecan(Clone : A7L6)
Product Sizes
100 µg
£716.00
36-1248-100UG
About this Product
- SKU:
- 36-1248
- Additional Names:
- HSPG2
- translate.label.attr.clone:
- A7L6
- Clonality:
- Monoclonal
- Extra Details:
- This MAb specifically precipitates heterogeneous material of high MW; identified as perlecan; a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin; fibronectin; or dermatran sulfate proteoglycan. Because of perlecan s strategic location and ability to store and protect growth factors; it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus; perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.
- Format:
- Purified
- Host:
- Rat
- Immunogen:
- Murine EHS laminin prepaRation
- Isotype:
- Rat IgG2a; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
