Monoclonal Antibody to HLA-DRB (MHC II)(Clone : SPM423)
Product Sizes
100 µg
£716.00
36-1235-100UG
About this Product
- SKU:
- 36-1235
- Additional Names:
- HLA-DRB1||HLA-DRB2
- translate.label.attr.clone:
- SPM423
- Clonality:
- Monoclonal
- Extra Details:
- This MAb reacts with a 28kDa chain of HLA-DRB1 antigen; a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. The L243 antibody recognizes a different epitope than the LN3 monoclonal antibody; and these antibodies do not cross-block binding to each other's respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells; activated T-cells; monocytes/macrophages; dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules; HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Activated human peripheral blood mononuclear cells
- Isotype:
- Mouse IgG2b; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
