Monoclonal Antibody to EMI1 (Early Mitotic Inhibitor-1)(Clone : EMI1/1176)
Product Sizes
100 µg
£716.00
36-1169-100UG
About this Product
- SKU:
- 36-1169
- Additional Names:
- FBXO5||EMI1||FBX5
- translate.label.attr.clone:
- EMI1/1176
- Clonality:
- Monoclonal
- Extra Details:
- It recognizes a 56kDa protein; which is identified as Early Mitotic Inhibitor-1 (EMI1). It regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Emi1 is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The Emi1 protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition; Emi1 is transcriptionally induced by the E2F transcription factor. Emi1 overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of Emi1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (203 amino acid residues between aa 1-250) of human EMI1 protein
- Isotype:
- Mouse IgG2a; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
