Monoclonal Antibody to ER-beta1 (Estrogen Receptor beta-1)(Clone : ERb455)-PE
Product Sizes
0.5 ml
£716.00
36-1118-0.5ML
About this Product
- SKU:
- 36-1118
- Additional Names:
- ESR2||ESTRB||NR3A2
- translate.label.attr.clone:
- ERb455
- Clonality:
- Monoclonal
- Conjugate:
- PE
- Extra Details:
- Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors; including ER-alpha and ER-beta; contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus; though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events; including dissociation from heat shock proteins; receptor dimerization; phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- C-terminus fragment of recombinant human estrogen receptor beta protein
- Isotype:
- Mouse IgG2a; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
