Polyclonal Antibody to beta-Catenin (p120)
Product Sizes
100 µg
£716.00
36-1075-100UG
About this Product
- SKU:
- 36-1075
- Additional Names:
- CTNNB1||CTNNB||OK/SW-cl.35||PRO2286
- Clonality:
- Polyclonal
- Extra Details:
- Beta-catenin associates with the cytoplasmic portion of E-cadherin; which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues; beta-catenin is localized to the membrane of epithelial cells; consistent with its role in the cell adhesion complex. In breast ductal neoplasia; beta-catenin is usually localized in cellular membranes. However; in lobular neoplasia; a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms; including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally; some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining; mimicking the staining pattern observed with lobular breast carcinomas.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide from the middle of beta-Catenin (p120) protein
- Isotype:
- Rabbit IgG
- Purification:
- Affinity Chromatography
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
