Monoclonal Antibody to p27Kip1 (Mitotic Inhibitor/Suppressor Protein)(Clone : SX53G8)
Product Sizes
100 µg
£716.00
36-1008-100UG
About this Product
- SKU:
- 36-1008
- Additional Names:
- CDKN1B||KIP1
- translate.label.attr.clone:
- SX53G8
- Clonality:
- Monoclonal
- Extra Details:
- This MAb recognizes a 27kDa protein; identified as the p27Kip1; a cell cycle regulatory mitotic inhibitor. It is highly specific and shows no cross-reaction with other related mitotic inhibitors. In Western blotting of cell lysates from 7 human breast cancer cell lines (ZR75-1; ZR75-30; MCF-7; MDAMB453; T47D; CAL51; 734B); the antibody labels a single band corresponding to p27Kip1. It functions as a negative regulator of G1 progression and has been proposed to function as a possible mediator of TGF-alpha induced G1 arrest. p27Kip1 is a candidate tumor suppressor gene. Reportedly; low p27 expression has been associated with unfavorable prognosis in renal cell carcinoma; colon carcinoma; breast carcinomas; non-small-cell lung carcinoma; hepatocellular carcinoma; multiple myeloma; and lymph node metastases in papillary carcinoma of the thyroid; as well as a more aggressive phenotype in carcinoma of the cervix.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Purified GST-p27 fusion protein of human origin
- Isotype:
- Mouse IgG1; kappa
- Purification:
- Affinity Chromatography
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
