Polyclonal Antibody to SIRT1 (Ab-344)
Product Sizes
50 µl
£511.00
35-1871-50UL
100 µl
£581.00
35-1871-100UL
About this Product
- SKU:
- 35-1871
- Additional Names:
- SIR2L1
- Clonality:
- Polyclonal
- Extra Details:
- NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle; response to DNA damage; metobolism; apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA; leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators; thereby regulating target gene expression positively and negatively. Serves as a sensor of the cytosolic ratio of NAD+/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction. Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT).
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.342~346 (N-Y-T-Q-N) derived from Human SIRT1.
- Isotype:
- Rabbit IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
