Polyclonal Antibody to SKP2 (Ab-64)
Product Sizes
50 µl
£511.00
35-1868-50UL
100 µl
£581.00
35-1868-100UL
About this Product
- SKU:
- 35-1868
- Additional Names:
- FBXL1
- Clonality:
- Polyclonal
- Extra Details:
- Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression; signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1; CDT1; RBL2; KMT2A/MLL1; CDK9; RAG2; FOXO1; UBP43; and probably MYC; TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner; thereby regulating cell migration.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.62~66 (P-E-S-P-P) derived from Human SKP2.
- Isotype:
- Rabbit IgG
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
